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1

Property-Based Design of GPCR-Targeted Library.

Konstantin V. Balakin, Sergey E. Tkachenko, Stanley A. Lang, Ilya Okun, Andrey A. Ivashchenko, Nikolay P. Savchuk

Journal:

Année:

2003

Fichier:

PDF, 50 KB

2003

2

1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as Potent Caspase-3 Inhibitors.

Dmitri V. Kravchenko, Vladimir V. Kysil, Alexey P. Ilyn, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Journal:

Année:

2005

Fichier:

PDF, 21 KB

2005

3

ChemInform Abstract: 8-Sulfonyl-Substituted Tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 Receptor Antagonists.

Alexandre V. Ivachtchenko, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya M. Okun, Volodymyr M. Kysil

Journal:

Année:

2010

Fichier:

PDF, 19 KB

2010

4

ChemInform Abstract: 2-Substituted 5,6-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: New Series of Highly Potent and Specific Serotonin 5-HT6 Receptor Antagonists.

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Angela G. Koryakova, Oleg D. Mitkin, Sergey E. Tkachenko, Volodymyr M. Kysil, Ilya Okun

Journal:

Année:

2011

Fichier:

PDF, 22 KB

2011

5

Halogen substitution at the isoxazole ring enhances the activity of N-(isoxazolyl)sulfonamide endothelin antagonists

Ming Fai Chan, B. Raju, Adam Kois, Rosario S. Castillo, Erik J. Verner, Chengde Wu, Emily Hwang, Ilya Okun, Fiona Stavros, V.N. Balaji

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 257 KB

english, 1996

6

Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Angela G. Koryakova, Sergiy M. Kovalenko, Oleg D. Mitkin, Ilya M. Okun, Irina M. Ravnyeyko, Sergey E. Tkachenko, Oleg V. Zaremba

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 511 KB

english, 2010

7

Novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamides as selective GSK-3 inhibitors

Angela G. Koryakova, Yan A. Ivanenkov, Elena A. Ryzhova, Elena A. Bulanova, Ruben N. Karapetian, Olga V. Mikitas, Eugeny A. Katrukha, Vasily I. Kazey, Ilya Okun, Dmitry V. Kravchenko, Yan V. Lavrovsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 212 KB

english, 2008

8

Synthesis and biological evaluation of novel γ-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Eugene B. Frolov, Oleg D. Mitkin, Volodymyr M. Kysil, Alexander V. Khvat, Ilya M. Okun, Sergey E. Tkachenko

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 457 KB

english, 2009

9

Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles

Alexandre V. Ivachtchenko, Eugen B. Frolov, Oleg D. Mitkin, Sergei E. Tkachenko, Ilya M. Okun, Alex V. Khvat

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 379 KB

english, 2010

10

Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Dmitri E. Dmitriev, Elena S. Golovina, Elena S. Dubrovskaya, Madina G. Kadieva, Angela G. Koryakova, Volodymyr M. Kysil, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya M. Okun, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 638 KB

english, 2010

11

Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones

Dmitri V. Kravchenko, Volodymyr M. Kysil, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Journal:

European Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 321 KB

english, 2005

12

Thiophenesulfonamides as endothelin receptor antagonists

B. Raju, Chengde Wu, Adam Kois, Erik Verner, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 353 KB

english, 1996

13

Amide bond surrogates: A study in thiophenesulfonamide based endothelin receptor antagonists

B. Raju, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 370 KB

english, 1997

14

Search for surrogates: A study of endothelin receptor antagonist structure activity relationships

B. Raju, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 369 KB

english, 1997

15

2-Aryloxycarbonylthiophene-3-sulfonamides: Highly potent and etA selective endothelin receptor antagonists

B. Raju, Chengde Wu, Rosario Castillo, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 354 KB

english, 1997

16

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Volodymyr M. Kysil, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya Okun

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 834 KB

english, 2011

17

1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors

Dmitri V. Kravchenko, Vladimir V. Kysil, Alexey P. Ilyn, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 133 KB

english, 2005

18

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya M. Okun, Volodymyr M. Kysil

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 499 KB

english, 2010

19

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: New series of highly potent and specific serotonin 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Angela G. Koryakova, Oleg D. Mitkin, Sergey E. Tkachenko, Volodymyr M. Kysil, Ilya Okun

Journal:

European Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2011

20

The discovery and structure—activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ETB receptor

Ming Fai Chan, Adam Kois, Erik J. Verner, Bore G. Raju, Rosario S. Castillo, Chengde Wu, Ilya Okun, Fiona D. Stavros, V.N. Balaji

Journal:

Bioorganic & Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 1.57 MB

english, 1998

21

New methods to mimic nature in high-throughput screening

Okun, Ilya, Veerapandian, Pandi

Journal:

Nature Biotechnology

Année:

1997

Fichier:

PDF, 743 KB

1997

22

Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines: Selective Serotonin 5-HT6 Receptor Antagonists

Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kovalenko, Sergiy M., Mitkin, Oleg D., Okun, Ilya M., Ravnyeyko, Irina M., Tkachenko, Sergey E., Zaremba, Oleg

Journal:

Journal of Combinatorial Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 854 KB

english, 2010

23

(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: Potent and Selective Antagonists of the Serotonin 5-HT6 Receptor

Ivachtchenko, Alexandre V., Dmitriev, Dmitri E., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kysil, Volodymyr M., Mitkin, Oleg D., Okun, Ilya M., Tkachenko, Sergey E., Vorobiev, Anto

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2010

24

Synthesis and caspase-3 inhibitory activity of 8-sulfonyl-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines

Dmitri V. Kravchenko, Volodymyr M. Kysil, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 348 KB

english, 2005

25

Synthesis and Structure−Activity Relationship of 4-Substituted 2-(2-Acetyloxyethyl)-8-(morpholine- 4-sulfonyl)pyrrolo[3,4-c]quinoline- 1,3-diones as Potent Caspase-3 Inhibitors

Kravchenko, Dmitri V., Kuzovkova, Yulia A., Kysil, Volodymyr M., Tkachenko, Sergey E., Maliarchouk, Sergey, Okun, Ilya M., Balakin, Konstantin V., Ivachtchenko, Alexandre V.

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 215 KB

english, 2005

26

Discovery of TBC11251, a Potent, Long Acting, Orally Active Endothelin Receptor-A Selective Antagonist1

Wu, Chengde, Chan, Ming F., Stavros, Fiona, Raju, B., Okun, Ilya, Mong, Seymour, Keller, Karin M., Brock, Tommy, Kogan, Timothy P., Dixon, Richard A. F.

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 389 KB

english, 1997

27

Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines—Synthesis and ‘structure–activity’ relationship

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Volodymyr M. Kysil, Oleg D. Mitkin, Anton A. Vorobiev, Ilya Okun

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 985 KB

english, 2012

28

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3- b ]pyridine-5-carbonitriles Are Selective Inhibitors of Plasmodium falciparum Glycogen Synthase Kinase-3

Fugel, Wiebke, Oberholzer, Anselm Erich, Gschloessl, Bernhard, Dzikowski, Ron, Pressburger, Narkiss, Preu, Lutz, Pearl, Laurence H., Baratte, Blandine, Ratin, Morgane, Okun, Ilya, Doerig, Christian, K

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 4.42 MB

english, 2013

29

Structure−Activity Relationships of N 2 -Aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as Selective Endothelin Receptor-A Antagonists 1

Wu, Chengde, Chan, Ming F., Stavros, Fiona, Raju, B., Okun, Ilya, Castillo, Rosario S.

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 297 KB

english, 1997

30

Synthesis and Chemical Transformations of 6‐(Morpholine‐4‐sulfonyl)‐quinoline‐2,3,4‐tricarboxylic Acid

Kravchenko, Dmitri V., Kysil, Volodymyr M., Ilyn, Alexey P., Tkachenko, Sergey E., Maliarchouk, Sergey, Okun, Ilya M., Ivachtchenko, Alexandre V.

Journal:

Synthetic Communications

Année:

2006

Langue:

english

Fichier:

PDF, 94 KB

english, 2006

31

Synthesis of substituted diphenyl sulfones and their structure–activity relationship with the antagonism of 5-НТ6 receptors

Ivachtchenko, Alexandre, Golovina, Elena, Kadieva, Madina, Mitkin, Oleg, Tkachenko, Sergei, Okun, Ilya

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2013

32

Synthesis and Structure–Activity Relationship (SAR) of (5,7-Disubstituted 3-phenylsulfonyl-pyrazolo[1,5- a ]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT 6 Receptor (5-HT 6 R) Antagonists

Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Kysil, Volodymyr M., Mitkin, Oleg D., Tkachenko, Sergey E., Okun, Ilya M.

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2011

33

SPIE Proceedings [SPIE BiOS 2000 The International Symposium on Biomedical Optics - San Jose, CA (Saturday 22 January 2000)] Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation - High-throughput pharmocology system HT-PS 100: instrument for automated quantitative analysis of a ligand-receptor interaction based on ligand concentration-dependent functional responses in cells

Okun, Ilya, Kaler, Gregory V., Otto, Michael, Okun, Alex, Bornhop, Darryl J., Licha, Kai

Année:

2000

Langue:

english

Fichier:

PDF, 423 KB

english, 2000

34

NEW VARIANT OF THE PEIZINGER REACTION. SYNTHESIS AND CHEMICAL TRANSFORMATIONS OF SUBSTITUTED 2-AMINOMETHYL-QUINOLINE-3,4-DICARBOXYLIC ACIDS

Kravchenko, Dmitri V., Kysil, Volodymyr M., Tkachenko, Sergey E., Maliarchouk, Sergey, Okun, Ilya M., Ivachtchenko, Alexandre V.

Journal:

Heterocyclic Communications

Année:

2006

Langue:

english

Fichier:

PDF, 617 KB

english, 2006

35

Pyrrolo[3,4-c]Quinoline-1,3-Diones as Potent Caspase-3 Inhibitors: Synthesis and SAR of 8-Sulfamoyl-1,3-Dioxo-2,3-Dihydro-1H-Pyrrolo[3,4- c]Quinolines

Kravchenko, Dmitri, Kuzovkova, Julia, Kysil, Volodymyr, Tkachenko, Sergey, Malarchuk, Sergey, Okun, Ilya, Ivachtchenko, Alexandre

Journal:

Letters in Drug Design & Discovery

Année:

2006

Langue:

english

Fichier:

PDF, 55 KB

english, 2006

36

Caspase Activity Modulators as Anticancer Agents

Okun, Ilya, Balakin, Konstantin, Tkachenko, Sergey, Ivachtchenko, Alexandre

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 444 KB

english, 2008

37

AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation

Ivachtchenko, Alexandre V., Okun, Ilya, Aladinskiy, Vladimir, Ivanenkov, Yan, Koryakova, Angela, Karapetyan, Ruben, Mitkin, Oleg, Salimov, Ramiz, Ivashchenko, Andrey, Bezprozvanny, Ilya

Journal:

Journal of Alzheimer's Disease

Année:

2017

Langue:

english

Fichier:

PDF, 764 KB

english, 2017

38

AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders

Ivachtchenko, Alexandre V., Lavrovsky, Yan, Okun, Ilya

Journal:

Journal of Alzheimer's Disease

Année:

2016

Langue:

english

Fichier:

PDF, 3.54 MB

english, 2016

39

A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model

Strand, Martin F., Wilson, Steven R., Dembinski, Jennifer L., Holsworth, Daniel D., Khvat, Alexander, Okun, Ilya, Petersen, Dirk, Krauss, Stefan, Bernhard, Eric J.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 3.16 MB

english, 2011